261-266
| Structure-Based Design of a New Bisintercalating Anthracycline Antibiotic
Jonathan B. Chaires,
Fenfei Leng,
Teresa Przewloka,
Izabela Fokt,
Yi-He Ling,
Roman Perez-Soler, and
Waldemar Priebe
[Full Article -
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267-278
| Syntheses and Structure-Activity Relationships of Taxoids Derived from 14 -Hydroxy-10-deacetylbaccatin III
Iwao Ojima,
John C. Slater,
Scott D. Kuduk,
Craig S. Takeuchi,
Rayomand H. Gimi,
Chung-Ming Sun,
Young Hoon Park,
Paula Pera,
Jean M. Veith, and
Ralph J. Bernacki
[Full Article -
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279-285
| Synthesis and Structure-Activity Relationships of Nonaromatic Taxoids: Effects of Alkyl and Alkenyl Ester Groups on Cytotoxicity
Iwao Ojima,
Scott D. Kuduk,
Paula Pera,
Jean M. Veith, and
Ralph J. Bernacki
[Full Article -
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286-299
| Analogues of N -(4-Amino-4-deoxypteroyl)-N -hemiphthaloyl-L-ornithine (PT523) Modified in the Side Chain: Synthesis and Biological Evaluation
Andre Rosowsky,
Chitra M. Vaidya,
Henry Bader,
Joel E. Wright, and
Beverly A. Teicher
[Full Article -
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300-312
| 5-HT1A- versus D2-Receptor Selectivity of Flesinoxan and Analogous N 4-Substituted N 1-Arylpiperazines
Wilma Kuipers,
Chris G. Kruse,
Ineke van Wijngaarden,
Piet J. Standaar,
Martin Th. M. Tulp,
Nora Veldman,
Anthony L. Spek, and
Adriaan P. IJzerman
[Full Article -
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313-321
| Nicotinamide Derivatives as a New Class of Gastric H+/K+-ATPase Inhibitors. 1. Synthesis and Structure-Activity Relationships of N-Substituted 2-(Benzhydryl- and benzylsulfinyl)nicotinamides
Hideo Terauchi,
Akihiko Tanitame,
Keiko Tada,
Keiji Nakamura,
Yasuhiro Seto, and
Yoshinori Nishikawa
[Full Article -
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322-330
| Potent and Selective Non-Benzodioxole-Containing Endothelin-A Receptor Antagonists
Andrew S. Tasker,
Bryan K. Sorensen,
Hwan-Soo Jae,
Martin Winn,
Thomas W. von Geldern,
Douglas B. Dixon,
William J. Chiou,
Brian D. Dayton,
Samuel Calzadila,
Lisa Hernandez,
Kennan C. Marsh,
J. Ruth WuWong, and
Terry J. Opgenorth
[Full Article -
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331-341
| (3R)-N-(1-(tert-Butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H- 1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): A Potent and Orally Active Gastrin/CCK-B Antagonist
Graeme Semple,
Hamish Ryder,
David P. Rooker,
Andrzej R. Batt,
David A. Kendrick,
Michael Szelke,
Mitsuaki Ohta,
Masato Satoh,
Akito Nishida,
Shinobu Akuzawa, and
Keiji Miyata
[Full Article -
PDF] |
342-349
| Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 5. Telomerized Anionic Surfactants Derived from Amino Acids
Alain Leydet,
Véronique Barragan,
Bernard Boyer,
Jean Louis Montéro,
Jean Pierre Roque,
Myriam Witvrouw,
José Este,
Robert Snoeck,
Graciela Andrei, and
Erick De Clercq
[Full Article -
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350-356
| Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 6. Micelle-like Anti-HIV Polyanionic Compounds Based on a Carbohydrate Core
Alain Leydet,
Christine Jeantet-Segonds,
Corinne Bouchitté,
Céline Moullet,
Bernard Boyer,
Jean Pierre Roque,
Myriam Witvrouw,
José Este,
Robert Snoeck,
Graciela Andrei, and
Erik De Clercq
[Full Article -
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357-361
| Cross-Linking and Sequence Specific Alkylation of DNA by Aziridinyl Quinones. 2. Structure Requirements for Sequence Selectivity
Rob H. J. Hargreaves,
Stephen P. Mayalarp,
John Butler,
Simon R. McAdam,
C. Caroline O'Hare, and
John A. Hartley
[Full Article -
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362-369
| Selectin-Ligand Interactions Revealed by Molecular Dynamics Simulation in Solution
Hideki Tsujishita,
Yasuyuki Hiramatsu,
Noriko Kondo,
Hiroshi Ohmoto,
Hirosato Kondo,
Makoto Kiso, and
Akira Hasegawa
[Full Article -
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370-376
| Analogues of Methotrexate in Rheumatoid Arthritis. 1. Effects of 10-Deazaaminopterin Analogues on Type II Collagen-Induced Arthritis in Mice
Joseph I. DeGraw,
William T. Colwell,
Jac Crase,
R. Lane Smith,
James R. Piper,
William R. Waud, and
Francis M. Sirotnak
[Full Article -
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377-384
| Analogues of Methotrexate in Rheumatoid Arthritis. 2. Effects of 5-Deazaaminopterin, 5,10-Dideazaaminopterin, and Analogues on Type II Collagen-Induced Arthritis in Mice
James R. Piper,
Joseph I. DeGraw,
William T. Colwell,
Cheryl A. Johnson,
R. Lane Smith,
William R. Waud, and
Francis M. Sirotnak
[Full Article -
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385-390
| Structure-Activity Studies on 2-Methyl-3-(2(S)-pyrrolidinylmethoxy)pyridine (ABT-089): An Orally Bioavailable 3-Pyridyl Ether Nicotinic Acetylcholine Receptor Ligand with Cognition-Enhancing Properties
Nan-Horng Lin,
David E. Gunn,
Keith B. Ryther,
David S. Garvey,
Diana L. Donnelly-Roberts,
Michael W. Decker,
Jorge D. Brioni,
Michael J. Buckley,
A. David Rodrigues,
Kennan G. Marsh,
David J. Anderson,
Jerry J. Buccafusco,
Mark A. Prendergast,
James P. Sullivan,
Michael Williams,
Stephen P. Arneric, and
Mark W. Holladay
[Full Article -
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